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當(dāng)前位置：首頁 > 產(chǎn)品展示 > Peprotech細(xì)胞因子 > 樹突狀細(xì)胞研究相關(guān)蛋白 > 美國Peprotech Recombinant Human IL-12

名稱	美國Peprotech Recombinant Human IL-12
型號
更新時(shí)間	2023-09-25
特點(diǎn)	IL-12細(xì)胞介導(dǎo)的免疫應(yīng)答是一個強(qiáng)有力的監(jiān)管機(jī)構(gòu),它誘發(fā)IFN-γ生產(chǎn)被NK細(xì)胞和T細(xì)胞。它是由激活單核細(xì)胞/巨噬細(xì)胞細(xì)胞,B淋巴細(xì)胞和結(jié)締組織肥大細(xì)胞類型。在其生物活性IL-12促進(jìn)增長和激活NK活性,CD4 +和CD8 +細(xì)胞和誘發(fā)IFN-γTh1細(xì)胞生產(chǎn)的發(fā)展。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human IL-12

二.Catalog Number:200-12

三.Synonyms:

NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, IL-12p70

四.Description:

IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

五.AA Sequence:

p35 Subunit: RNLPVA TPDPGMFPCL HHSQNLLRAV SNMLQKARQT LEFYPCTSEE IDHEDITKDK TSTVEACLPL ELTKNESCLN SRETSFITNG SCLASRKTSF MMALCLSSIY EDLKMYQVEF KTMNAKLLMD PKRQIFLDQN MLAVIDELMQ ALNFNSETVP QKSSLEEPDF YKTKIKLCIL LHAFRIRAVT IDRVMSYLNA S

p40 Subunit:IWELKK DVYVVELDWY PDAPGEMVVL TCDTPEEDGI TWTLDQSSEV LGSGKTLTIQ VKEFGDAGQY TCHKGGEVLS HSLLLLHKKE DGIWSTDILK DQKEPKNKTF LRCEAKNYSG RFTCWWLTTI STDLTFSVKS SRGSSDPQGV TCGAATLSAE RVRGDNKEYE YSVECQEDSA CPAAEESLPI EVMVDAVHKL KYENYTSSFF IRDIIKPDPP KNLQLKPLKN SRQVEVSWEY PDTWSTPHSY FSLTFCVQVQ GKSKREKKDR VFTDKTSATV ICRKNASISV RAQDRYYSSS WSEWASVPCS

六.Source:CHO cells

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the induction of IFN-γ from NK cells co-stimulated with IL-18 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶ units/mg.

九.Cross Reactivity:Bacteria, Monkey, Mouse, Human, Leech

十.www.peprotech.com