| 名稱 | Recombinant Human Flt3-Ligand |
| 型號 | |
| 更新時間 | 2023-09-24 |
| 特點 | Flt3-Ligand是一種生長因子,調(diào)節(jié)早期造血細(xì)胞的增殖。Flt3-Ligand結(jié)合細(xì)胞表達酪氨酸激酶受體Flt3。Flt3-Ligand,本身不刺激早期造血細(xì)胞的增殖,但synergizes與其他模型和白細(xì)胞介素誘導(dǎo)生長和分化。} |
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一.產(chǎn)品名稱：Recombinant Human Flt3-Ligand
二.貨號Catalog Number:AF-300-19
三.同義Synonyms:Fms-related tyrosine kinase 3 ligand
四.描述Description:
Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues. Manufactured using all non-animal reagents.
五.AA序列AA Sequence:
TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
六.來源Source:E.coli
七.純度Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.生物活性Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
九.交叉性Cross Reactivity:
Monkey, Mouse, Rat, Human, Rabbit, Human + Mouse
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電話/傳真：13366128764
手機：15311648455
地址：北京市海淀區(qū)廂黃旗2號樓1層4-179室